Degenerative Arthritis – Latest Advancements in Treatments

Category: Blog

Adipose derived stem cells and PRP demonstrate significant healing in patients with degenerative arthritis

We see many patients with chronic progressive degenerative osteoarthritis. Often we see them following a recommendation to total joint replacement of which they do not want. A main reason, as we know, total joint replacements are associated with significant risks and side-effects including failure of the replacement.

New Research

A new study in the Journal of translational medicine suggests that SVFs (Stromal vascular fraction of adipose (fat) tissue (the source of stem cells)),combined with PRP (Platelet Rich Plasma therapy) and administered by injection, demonstrate healing potential in patients with degenerative osteoarthritis. Patients demonstrated significant improvements in their degenerative osteoarthritis leading to a better quality of life. These improvements included a clinically significant reduction in pain.

How much improvement?

  • Pain functional status of the knee was improved 12 months post injection in all patients and this improvement was maintained at the 2 year time point of the study’s follow up.
  • Some patients showed improvements as early as 3 and 6 months after the injection of (stem cells) and PRP.
  • The stem cell/ PRP injections also significantly reduced the requirement of pain medication in 8 out of 10 patients. These medications are often associated with undesired side effects and although it may mask the pain, it does not help the underlying disease.
  • In addition, clinical improvement corresponded well with improvement on MRI imaging.
  • The researchers were able to demonstrate safety with no serious side effects reported during the 2 year follow-up. 1

What Does This Mean?

The importance of the study above shows that combining adipose derived stem cells and PRP, doctors were able to bring about long-lasting pain relief and joint repair.

At the Magaziner Center, Dr. Greenberg treats the area of injury or arthritis with both stem cells and PRP. If stem cells are the seeds in the lawn, PRP is the fertilizer that helps the lawn grow. PRP is a combination of growth factors and platelets naturally found in the body. They provide cell signals (direct) and nourishment to help the stem cells flourish and develop into new joints, ligaments, tendons, and other body parts.

More About PRP

PRP not only triggers stem cell development, but can also help stem cells regenerate on their own inside the body, and can also attract circulating stem cells to the area of injury. We have used PRP alone in the treatment of many injuries and pain problems.

Most cases of stem cell and PRP treatments are successful, and avoid the pain, disability, down time, and risk associated with major surgery. There is minimal recovery from a stem cell or PRP treatment, usually mediated by soreness in the area that was treated, and there is also a risk of bruising.

Learn about PRP treatments at Magaziner.

There have been no reports of serious adverse effects in the scientific literature when adult mesenchymal stem cells are used in these procedures. Afterwards, the patient is encouraged to use the joint normally, and follow up treatments of PRP are given in monthly intervals to continue to allow the stem cells to do their work. Since stem cell treatment is very safe, it can be repeated in the joint if necessary to obtain optimal results. Also, having treatment with stem cells would not make a person ineligible for surgery.

To learn if you are a candidate for PRP, or want more information on how The Magaziner Center for Wellness can help with your arthritis visit us today.

1 Bansal, H., Comella, K., Leon, J., Verma, P., Agrawal, D., Koka, P., & Ichim, T. (2017). Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis. Journal of Translational Medicine, 15, 141.