Menopausal mood symptoms

Category: Blog, mood - memory

“It is suggested that declines in estrogen around menopause are associated with declines in cognitive functioning as well as increased risk of depressive symptoms and depressive disorders.” (1)

In recent research clinical evidence for the effectiveness of compounded BHRT (and) provides clear evidence that compounded BHRT is effective for reducing menopausal mood symptoms. Larger studies are needed to examine the impact of compounded BHRT on vasomotor symptoms, myocardial infarction, and breast cancer. (2)


Mood swings and irritability are often considered one and the same by many doctors. Going from a happy euphoric feeling to a sad and depressed state seemingly at the snap of the fingers is a well documented menopause symptom that is directly related to hormone imbalance.

Estrogen levels influences seroton levels. Serotonin is a neurotransmitter that regulates mood. The rising or falling estrogen levels causes an increased production of serotonin which causes emotional swings.

See our article on
Women, Estrogen, Serotonin, Depression

The Magaziner Center for Wellness treats five to 10 women per day for menopausal syndrome. Until the year 2002, most women were placed on (synthetic) Hormone Replacement Therapy by their gynecologists. HRT, as it is known, was highly controversial because of the link between synthetic hormones and increased risk of breast cancer, heart disease, stroke and blood clots. Since that time, use of synthetic hormones has become virtually obsolete.

At the Magaziner Center for Wellness, we use bio-identical hormones (BHRT). Bio-identical hormones are different than synthetic hormones because they are structurally and chemically the same as the three estrogens naturally produced by the body – Estriol, Estradiol and Estrone and natural progesterone, testosterone and others, depending on the needs of the patient. Synthetic hormones – namely conjugated estrogens feature a manipulated form of the three estrogens while Medroxyprogesterone Acetate (MPA), which is found in Provera, is a synthetic form of progesterone.

The body responds to and metabolizes synthetic hormones differently than bio-identical hormones. Bio-identical hormones are far safer and more effective than synthetics and, therefore, have grown in use. At the Magaziner Center for Wellness, we have been treating patients for more than 25 years with BHRT.  Each is compounded by pharmacists – meaning they are handmade using a mortar and pestle – so that they are customized for each patient based on the strength needed by each individual according to her needs and wants.

Before formulating a treatment plan, the doctors at the Magaziner Center for Wellness analyze each patient individually using 24 hour urine specimens and comprehensive blood work. We look at the metabolites of estrogen in a woman’s body, as certain metabolites can increase the risk of breast or gynecological cancers. We also look at both thyroid and adrenal function. We rarely use saliva tests as they are not comprehensive enough to give information about hormone metabolites and to ascertain the best course of treatment for a patient.

We use a self-scoring system each time a patient comes in so that we can further customize and assess the success of her treatment as it progresses. This allows us to tweak the dosages so that we can optimize the patient’s results.mong our patients at the Center.

Call our office for more information
Phone: 856-324-60331.

1. Ruiz AD. Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study. BMC Womens Health. 2011; 11: 27. Published online 2011 June 8. doi: 10.1186/1472-6874-11-27

2.Weber MT, Maki PM, McDermott MP.  Cognition and mood in perimenopause: A systematic review and meta-analysis. J Steroid Biochem Mol Biol. 2013 Jun 13. pii: S0960-0760(13)00111-8. doi: 10.1016/j.jsbmb.2013.06.001. [Epub ahead of print]