Hormone Replacement Therapy and Heart Failure

Category: Blog

More than 20 years ago, researchers in Denmark started studying some 1,006 healthy women aged 45-58 who were recently postmenopausal or had perimenopausal symptoms. They decided to give about half (502 women) hormone replacement therapy, and half (504) women, no therapy. The study was stopped after about 11 years because of  adverse reports from other trials. (The Woman’s health Inititive of 2002). Regarldess they continued to follow these women after the treatments were halted. Ten years later  they published their research. What they found was:

“After 10 years of randomised treatment, women receiving hormone replacement therapy early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, without any apparent increase in risk of cancer, venous thromboembolism, or stroke.” (1)

Yet other research concludes: “(Hormone Therapy) is not indicated for primary or secondary prevention of cardiovascular disease or dementia, nor for preventing deterioration of cognitive function in postmenopausal women.”(2)

And even moreso: “Women who receive 2-3 years of HRT after menopause do not have increased all-cause mortality, and results of the present study suggest relative cardiovascular benefits compared to those who had not used hormones.”(3)

Hormone Replacement Therapy

“Many women have been denied or have discontinued Hormone Replacement Therapy because of the risks associated with synthetic hormones despite evidence that estrogen could help protect against cardiovascular disease. Women experience heart attacks and strokes approximately 10 years later than men, which is thought to be the result of declining levels of circulating estrogen. Estrogen helps to raise HDL, lower LDL and total cholesterol. However in recent years, large clinical trials have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease.

Are Bio-Identical Hormones the Answer to CardioVascular risk and Menopausal Symptoms?

At the Magaziner Center for Wellness, we treat many women, every day for menopausal syndrome.We use bio-identical hormones (BHRT). Bio-identical hormones are different than synthetic hormones because they are structurally and chemically the same as the three estrogens naturally produced by the body – Estriol, Estradiol and Estrone and natural progesterone, testosterone and others, depending on the needs of the patient. Synthetic hormones – namely conjugated estrogens feature a manipulated form of the three estrogens while Medroxyprogesterone Acetate (MPA), which is found in Provera, is a synthetic form of progesterone.

The body responds to and metabolizes synthetic hormones differently than bio-identical hormones. Bio-identical hormones are far safer and more effective than synthetics and, therefore, have grown in use. At the Magaziner Center for Wellness, we have been treating patients for more than 25 years with BHRT.

Is bio-identical homrones right for you? This is best answered in a consultation with your physician and following appropriate lab work.

Email: magazinercenter@gmail.com

1. Schierbeck LL, Rejnmark L, Tofteng CL, Stilgren L, Eiken P, Mosekilde L, Køber L, Jensen JE. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409. doi: 10.1136/bmj.e6409.

2. Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2012 Jul 11;7:CD004143. Cochrane Database Syst Rev. 2012 Jul 11;7:CD004143.

3. Alexandersen P, Tanko LB, Bagger YZ, Qin G, Christiansen C.The long-term impact of 2-3 years of hormone replacement therapy on cardiovascular mortality and atherosclerosis in healthy women. Climacteric. 2006 Apr;9(2):108-18.