Rice bran and cancer

Category: Blog, Cancer

Medical research is suggesting that  dietary rice bran may exert beneficial effects against several types of cancer, such as breast, lung, liver, and colorectal cancer.

In the newest research doctors say:
Rice bran compounds support Natural Killer cells (cancer killer cells)1.
Components in rice bran may present chemopreventive potential  options.2

The chemopreventive potential has been related to the bioactive phytochemicals present in the bran portion of the rice. Studies, as those shown above, have shown that the anticancer effects of the rice bran–derived bioactive components work through their ability to induce cancer cell death, prevent cancer cell proliferation, and alter cell cycle progression in malignant cells.

Rice bran phytochemicals have also been shown to activate anticancer immune responses as well as affecting the colonic tumor microenvironment in favor of enhanced colorectal cancer chemoprevention. This is accomplished through the modulation of gut microflora communities and the regulation of carcinogen-metabolizing enzymes.

The establishment of dietary rice bran as a practical food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention for the global population.3

In other research Juice from rice cells knocked out two kinds of human cancer cells as well or better than the potent anti-cancer drug Taxol in lab tests conducted by a Michigan Technological University scientist. 4

Recently doctors found that Phytic acid (PA) a polyphosphorylated carbohydrate that can be found in high amounts in most cereals, legumes, nut oil, seeds and soy beans can play a significant role in inhibition of colorectal cancer. 5

It is easy to see why Rice Bran is called the Miracle Food or the Super Food. The disease fighting properties, the high fiber, the high antioxidant levels and now researchers say it may make a great energy source in industry by way of bioethanol and biodiesel fuels.

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1. Pérez-Martínez A, Valentín J, Fernández L, et al. Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo. Cytotherapy. 2014 Dec 22. pii: S1465-3249(14)00849-4. doi: 10.1016/j.jcyt.2014.11.001. [Epub ahead of print]

2. Eitsuka T, et al. Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid. Biochem Biophys Res Commun. 2014 Oct 24;453(3):606-11. doi: 10.1016/j.bbrc.2014.09.126. Epub 2014 Oct 5.

1 Henderson AJ, et al. Chemopreventive Properties of Dietary Rice Bran: Current Status and Future Prospects. doi: 10.3945/​an.112.002303. Adv Nutr September 2012 Adv Nutr vol. 3: 643-653, 2012. Rice bran and cancer.

2. Aparna Deshpande, Surendar R. Dhadi, Elizabeth J. Hager, Wusirika Ramakrishna. Anticancer Activity of Rice Callus Suspension Culture. Phytotherapy Research, 2012; 26 (7): 1075 DOI: 10.1002/ptr.3699

3. Saad N, Esa NM, Ithnin H. Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA). Asian Pac J Cancer Prev. 2013;14(5):3093-9.