Are Stem Cell Injections For Knee Pain Long-Lasting?

Category: Blog

The challenges people face with knee osteoarthritis are many. One challenge is what type of treatments should they have short of knee replacement? For many people they have made a trip to the orthopedist and the run down of treatment options available seemingly all carry the same outlook. “Eventually will will need a knee replacement.”

Why are these treatments so short-term?

A recent paper in the publication Clinical and translational medicine, stated,  “Current treatment strategies for osteoarthritis are inadequate and costly. Due to the increasing incidence and prevalence of osteoarthritis, more innovative and effective therapeutic modalities need to be investigated, including mesenchymal stem cell based therapy.”1

Many of the patients we see at the Magaziner Center for Wellness are perfectly described in the above paragraph:

  • They have osteoarthritis
  • They had a lot of treatments that were inadequate
  • They have had a lot of costly treatments prescribed

In our practice, these inadequate treatments would be such things, as listed by our patients, as cortisone injections, hyaluronic injections, painkillers, anti-inflammatories, and arthroscopic surgery. Most patients come to our office because they were finally (they got old enough) recommended for knee replacement surgery.

At Magaziner Center For Wellness, We See a Lot of Knee Pain Patients

Stem Cell Injections are part of our treatment plan for joint injuries and chronic pain. This is because we have seen inadequate treatments play out, and because we have always sought more innovative and effective therapeutic modalities, including mesenchymal stem cell based therapy.

We have specialized, since 1999, in the non-surgical treatment of joint injuries, using techniques such as prolotherapy, platelet rich plasma therapy, and stem cell therapy to regenerate joint tissue. We have performed tens of thousands of procedures. This experience allows us to take a dual approach to joint injury with the use of stem cells and PRP to treat within the joint, and the use of prolotherapy to strengthen and regenerate the supporting structure of the joint.

Below is some new research which will help answer your questions on stem cell injection for knee osteoarthritis

Research says stem cell injections to knee are long-lasting

Doctors at Chinese Academy of Medical Sciences and China’s Cellular Biomedicine Group found that one of the reasons stems cell therapy is effective is that after a single injection, the new stems cells remained active (healing) for 10 weeks. The doctors also noted that this extended duration stay is required for stem cells to exert their functions on promoting joint regeneration and/or cartilage protection.2

Doctors at the Department of Orthopedics, Medical College of Shihezi University in China published findings suggested in treated patients stem cell therapy offered long-term relief of symptoms. The doctors were able to conclude their long-term study by saying: “Stem Cell treatment in patients with knee osteoarthritis showed continual efficacy for 24 months compared with their pre-treatment condition. “3

In the International journal of rheumatic diseases, doctors from Tehran University  found at the end of the five-year follow-up that stem cell treated knees were still better than before treatment.4

Doctors affiliated with the University of Louisville also reported good news for athletes seeking knee osteoarthritis repair without surgery, reporting that stem cell treatments not only restored damaged cartilage, but the repair also acted  to prevent future deterioration of the knee joint.5

University research from Italy says stem cells have shown promising results in relieving pain and reducing inflammation in patients with more advanced osteoarthritis, helping many halts the progression of the disease and the need for joint replacement.6

We Have Seen Success

Most cases of stem cell and platelet rich plasma (PRP) treatments are successful, yielding positive results. We have had pro-athletes, who had been sidelined, resume their high-intensity career. We have witnessed elderly patients, who were once wheelchair-bound, walk again without assistance. We have had patients with chronic hereditary and acquired diseases improve to a functional level that allowed them to again enjoy life.

Our patients have seen an end to their pain and a return to their normal level of functioning, even after failing surgery to a torn meniscus.

There have been no reports of serious adverse effects in the scientific literature or in our patients when adult stem cells are used.

Why Is It Preferred?

Stem Cell Therapy is preferable to surgery and often times makes it possible to avoid surgery, which otherwise would have been necessary.

As opposed to the pain, disability, downtime, and risk associated with major surgery, stem cell therapy has very minimal recovery time. There may be a soreness in the treated area and the possibility of bruising, but patients are able to continue their everyday activities while undergoing treatment. Because we use only local anesthesia, our patients are not at risk to the possibility of cognitive decline that can accompany prolonged general anesthesia.

Furthermore, in contrast to joint replacement surgery, the risk of infection is practically zero, where an infected artificial knee, hip, or shoulder can lead to weeks to months of hospitalization and disability.

We Are FDA Compliant

We follow strict FDA guidelines in the use of stem cells, and at no time do we manipulate, expand, or grow stem cells in culture. We believe the best stem cell therapies are derived from the patient in high concentration and placed back into the area of treatment.

Manipulation and replication of stem cells in culture may inactivate these cells and may also lead to the development a of mutation that could lead to cancer. The use of the patient’s own adult stem cells, as is performed at the Magaziner Center, avoids this problem.

Contact us today for a free consultation by calling 856-424-8222.


1. Burke J, Hunter M, Kolhe R, Isales C, Hamrick M, Fulzele S. Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis. Clinical and Translational Medicine. 2016;5:27. doi:10.1186/s40169-016-0112-7.

2 Li M, Luo X, Lv X, et al. In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model. Stem Cell Research & Therapy. 2016;7:160. doi:10.1186/s13287-016-0420-2.

3 Cui G-H, Wang YY, Li C-J, Shi C-H, Wang W-S. Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis. Experimental and Therapeutic Medicine. 2016;12(5):3390-3400. doi:10.3892/etm.2016.3791.

4 Davatchi F, Sadeghi Abdollahi B, Mohyeddin M, Nikbin B. Mesenchymal Stem Cell Therapy for knee osteoarthritis: 5 years follow-up of three patients. Int. J. Rheum. Dis. 2015 May 20. doi: 10.1111/1756-185X.12670.

5  Nyland J, Mattocks A, Kibbe S, Kalloub A, Greene JW, Caborn DNM. Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update.Open Access Journal of Sports Medicine. 2016;7:21-32. doi:10.2147/OAJSM.S72332.

  1. de Girolamo L, Kon E, Filardo G, et al. Regenerative approaches for the treatment of early osteoarthritis Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):1826-35. doi: 10.1007/s00167-016-4125-y. Epub 2016 Apr 27.