New Research on Weight Loss and Knee Pain - Magaziner

New Research on Weight Loss and Knee Pain

The holistic approach weight loss, hormones, knee pain

Doctors at Monash University in Australia examined whether concentrations of circulating sex steroid hormones in overweight and obese men were associated with higher risk of primary knee and hip arthroplasty (replacement). The answer: Yes, low plasma androstenedione (testosterone) concentration is associated with an increased risk of both knee and hip arthroplasty for osteoarthritis in overweight and obese men. (6)


1 Hill DS, Freudmann M, Sergeant JC, Board T. Management of symptomatic knee osteoarthritis in obesity: a survey of orthopaedic surgeons’ opinions and practice. European Journal of Orthopaedic Surgery & Traumatology. 2017 Dec 28:1-8.

2 Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Chanchek N, Guimaraes JB, Mbapte Wamba J, Facchetti L, McCulloch CE, Link TM. Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 months? Data from the Osteoarthritis Initiative. Radiology. 2017 May 2;284(2):508-20.

3 Gersing AS, Solka M, Joseph GB, et al. Progression of Cartilage Degeneration and Clinical Symptoms in Obese and Overweight Individuals is Dependent on the Amount of Weight Loss: 48-Month Data from the Osteoarthritis Initiative. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2016;24(7):1126-1134. doi:10.1016/j.joca.2016.01.984.

4 Lee J, Song J, Hootman JM, et al. Obesity and Other Modifiable Factors for Physical Inactivity Measured by Accelerometer in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative (OAI). Arthritis care & research. 2013;65(1):53-61. doi:10.1002/acr.21754.

5. Huebner JL, Landerman LR, Somers TJ, Keefe FJ, Guilak F, Blumenthal JA, Caldwell DS, Kraus VB. Exploratory Secondary Analyses of a Cognitive-Behavioral Intervention for Knee Osteoarthritis Demonstrate Reduction in Biomarkers of Adipocyte Inflammation. Osteoarthritis Cartilage. 2016 Apr 15. pii: S1063-4584(16)30015-2. doi: 10.1016/j.joca.2016.04.002.

6 Hussain SM, Cicuttini FM, Giles GG, Graves SE, Wang Y. Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men. Osteoarthritis Cartilage. 2016 Apr 12. pii: S1063-4584(16)30024-3. doi: 10.1016/j.joca.2016.04.008.

7 Losina E, Walensky RP, Reichmann WM. Impact of obesity and knee osteoarthritis on morbidity and mortality in older Americans. Ann Intern Med. 2011 Feb 15;154(4):217-26.

8 Atukorala I, Makovey J, Lawler L, Messier SP, Bennell K, Hunter DJ. Is there a dose response relationship between weight loss and symptom improvement in persons with knee osteoarthritis? Arthritis Care Res (Hoboken). 2016 Jan 19. doi: 10.1002/acr.22805.

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