Research on nutritional compounds and Alzheimer’s Disease

Belgian doctors have just published a very fascinating research article. In it they acknowledge that dietary interventions such as caloric restriction extend lifespan and health span, slows down the aging process and improves memory performance. Caloric restriction also retards and slows down the progression of different age-related diseases, such as Alzheimer’s disease. This is covered in our article Caloric restriction may prevent memory loss as we age.

What is most fascinating about this new research is that the Belgian doctors suggest that you can get the benefits of caloric restriction without the restriction by using caloric restriction mimetics (a mimic). One of those mimics is Resveratrol.1

Caloric restriction mimetics target increasing energy metabolism to potentially mimic the beneficial health-promoting and anti-aging effects without the need to reduce food intake significantly.2

The list of growing research in support of Resveratrol, vitamin D and other nutrients for the aging brain are beginning to show positive proof that nutritional supplements and proper diet have a positive effect the aging brain.

In the largest nationwide clinical trial to study high-dose resveratrol long-term in people with mild to moderate Alzheimer’s disease found that a biomarker that declines when the disease progresses was stabilized in people who took the purified form of resveratrol.2

Resveratrol is a naturally occurring compound found in foods such as red grapes, raspberries, dark chocolate and some red wines. Resveratrol and similar compounds are being tested in many age-related disorders including cancer, diabetes and neurodegenerative disorders.


Doctors confirmed that resveratrol has exhibited significant antioxidant, anti-inflammatory, anti-viral, and anti-cancer properties. Although resveratrol was first isolated in 1940, it was not until the last decade that it was recognised for its potential therapeutic role in reducing the risk of neurodegeneration, and  Alzheimer disease in particular.

In the research published in the medical journal Current Topics in Medicinal Chemistry, Resveratrol has demonstrated neuroprotective effects in several studies. Apart from its potent antioxidant and anti-inflammatory roles, evidence suggests that resveratrol also facilitates preventing and slowing down Alzheimer’s disease pathology. The same researchers warn that resveratrol alone may not be an effective single therapy, but coupled to other compounds might yet prove an effective therapy with multiple targets.

Vitamin D3, Omega-3, and B Vitamins Coupling Compounds

Scientists say they have identified functions regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer’s disease.

Published in the Journal of Alzheimer’s Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein.

The researchers say that their findings demonstrate that active forms of vitamin D3 may be an important regulator of immune activities of macrophages in helping to clear amyloid plaques by directly regulating the expression of genes, as well as the structural physical workings of the cells.4

In another study we reported on, that elevation of certain nutrients namely omega-3 fatty acids and vitamins B, C, D and E in blood plasma of older patients were related to better thinking abilities and a larger brain volume.

Using Brain imaging and blood plasma tests to understand how nutrients alter brain structure, researchers writing in the medical journal Neurology say “people with a vitamin profile high in B, C, D, E, those particular nutrients seem to be working together on some level…Having high scores for those vitamins was associated with better cognitive function and larger brain volume.” Omega-3 was associated with the ability to do higher levels of complex or “executive” thought. 5

At the Magaziner Center for Wellness in Cherry Hill, New Jersey, we begin our treatment of Alzheimer’s patients with a full analysis of a person’s mitochondrial function, including testing for heavy metal toxicity, specifically related to aluminum which has been linked to Alzheimer’s. We have also seen many patients who have high levels of lead, mercury, cadmium or arsenic. If detected, we utilize chelating agents to rid the body of these metals, as well as other natural detoxification techniques.

We work to repair oxidative damage with Hyperbaric Oxygen therapy and the use of antioxidant nutritional supplements including Vitamins E, Vitamin B12 and folate, amino acids, and fatty acids as well as the intake of “superfoods” known for their natural healing properties.

In addition, we utilize intravenous vitamin infusions to help regulate any nutrient imbalances and vitamin and mineral deficiencies. To balance the flow of energy and help promote clearer thinking, we also utilize ONDAMED®, a high-tech biofeedback machine designed in Germany.

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1 Van Cauwenberghe C, Vandendriessche C, Libert C, Vandenbroucke RE. Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease. Mamm Genome. 2016 Aug;27(7-8):300-19. doi: 10.1007/s00335-016-9647-6. Epub 2016 May 30. Review.

Turner RS, et al.  A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer diseaseNeurology, 2015; DOI:10.1212/WNL.0000000000002035

3. Braidy N, Jugder BE, Poljak A, Jayasena T, Mansour H, Nabavi SM, Sachdev P, Grant R.
Curr Top Med Chem. 2016 Feb 4. [Epub ahead of print] Resveratrol as a Potential Therapeutic Candidate for the Treatment and Management of Alzheimer’s Disease.  Curr Top Med Chem. 2016 Feb 4. [Epub ahead of print]

4. 6-March-2012 – Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer’s. Press Release of the Journal of Alzheimer’s Disease

5. Bowman GL, Silbert LC, Howieson D. et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology WNL.0b013e3182436598; published ahead of print December 28, 2011