Alzheimer’s disease is a complicated and complex disease. At the Magaziner Center for Wellness, we approach Alzheimer’s disease as a multi-factorial challenge. Research has shown us that there can be many factors that can cause and contribute to Alzheimer’s Disease. These range from environmental toxins to nutrition to heavy metal toxicity. Every day new studies come out suggesting new revelations in how the disease develops, how it may be prevented, and how it may be treated. There is currently no single treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals may lead to the onset of Alzheimer’s disease symptoms. Addressing these changes as they occur may have the desired preventative effect.
In our office, patients with concerns surrounding Alzheimer’s disease are examined in a way to help understand his/her unique biochemistry. A biochemistry which reacts to pollutants and toxins differently, and requires an individualized course of treatment. While the disease may look similar from person to person, we are not treating the disease, we are healing the individual.
In this article we will focus on one of the factors that we look at in our patients with Alzheimer’s disease concerns, the role of excessive iron levels in the body and brain.
The role of iron in Alzheimer’s disease
In the March 2019 edition of the medical journal Neural regeneration research, doctors from the Universities of Louisiana and Iowa write, “Neurodegenerative diseases such as Alzheimer’s, Huntington’s and Parkinson’s diseases have (a) multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multi-target-directed ligands (a chelator – something to remove heavy toxic metals from the body) to address the complementary pathways involved in these diseases. . . . ” Part of this need they add is a need to research “therapeutics based on iron chelation strategy.”(1)
Iron is an essential mineral for brain health and development. It can also be a villainous mineral when the delicate balance between the amounts of iron necessary for brain function is far exceeded. Excessive iron in the brain has been implicated in many neurological diseases including Alzheimer’s Disease.
It is hard to get rid of excess iron.
This was discussed in research by doctors at the The Florey Institute for Neuroscience and Mental Health at The University of Melbourne published in the Journal of neurochemistry (2)
“Brain iron homeostasis (balance) is increasingly recognized as a potential target for the development of drug therapies for aging-related disorders. Dysregulation of iron metabolism associated with cellular damage and oxidative stress is reported as a common event in several neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Iron plays a crucial role in maintaining normal physiological functions in the brain through its participation in many cellular functions such as mitochondrial respiration (the creation of energy), myelin synthesis (the creation of the protective myelin sheath that protects the nerves), and neurotransmitter synthesis and metabolism.
However, excess iron is a potent source of oxidative damage through radical formation and because of the lack of a body-wide export system, a tight regulation of its uptake, transport and storage is crucial in fulfilling cellular functions while keeping its level below the toxicity threshold.
Iron plays a fundamental role in maintaining the high metabolic and energetic requirements of the brain. However, iron has to be maintained in a delicate balance as both iron overload and iron deficiency are detrimental to the brain and can trigger neurodegeneration.”
In a study from 2018, published in the journal Frontiers in Neuroscience, (3) investigators added:
“Abnormal iron metabolism generates hydroxyl radicals. . . (it) triggers oxidative stress reactions, damages cell lipids, protein and DNA structure and function, and ultimately leads to cell death. There is an imbalance in iron homeostasis in Alzheimer’s disease. Excessive iron contributes to the deposition of β-amyloid (the main component of the amyloid plaques found in Alzheimer’s disease) and the formation of neurofibrillary tangles (simply protein plaque clumps), which in turn, promotes the development of Alzheimer’s disease.
Therefore, iron-targeted therapeutic strategies have become a new direction. Iron chelators . . . have received a great deal of attention and have obtained good results in scientific experiments and some clinical trials. . . ”
The theory is that chelation, with a special focus on iron ions, is a valuable approach for treating Alzheimer’s disease.
The role of iron in diabetes induced Alzheimer’s disease
The research above gives good evidence that iron and Alzheimer’s disease are linked. But at the onset of this article we told you that Alzheimer’s disease is a complex disease. Let’s throw diabetes now into the mix to illustrate this point.
In the journal Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, (4) investigators discussed this complexity:
“Several studies have demonstrated that diabetes involving insulin resistance and glucose tolerance could lead to Alzheimer’s disease, ultimately resulting in cognitive dysfunction. Even though the relationship between diabetes and Alzheimer’s disease was indicated by significant evidences, the critical mechanisms and metabolic alterations in diabetes induced Alzheimer’s disease are not clear.
Recently, iron metabolism has been shown to play multiple roles in the central nervous system. Iron deficiency and overload are associated with neurodegenerative diseases. . . previous studies have shown that iron is involved in the aggravation of insulin resistance. Considering these effects of iron metabolism in central nervous system, we expect that iron metabolism may play crucial roles in diabetic Alzheimer’s disease brain.”
So can you simply get rid of the iron without addressing concerns diabetes? Insulin-resistance? Glucose intolerance? These are just some of the compounding factors that can impact how you address the challenges of Alzheimer’s disease.
Chelation and Iron Toxicity
There are many ways to chelate iron out of the body. While the medical community does not agree on the best method of chelation, whether they come from the iron chelator drug classes, herbal or nutritional remedies such as curcumin and green tea extract or in the form of Intravenous EDTA chelation as we utilize in the Magaziner Center for Wellness, one thing that is in universal agreement is that iron overload is a problem, one of the problems in Alzheimer’s disease.
At the Magaziner Center for Wellness we begin our treatment of Alzheimer’s patients with a full analysis of a person’s mitochondrial function, including testing for heavy metal toxicity. If detected, we utilize chelating agents to rid the body of these metals, as well as other natural detoxification techniques.
We work to repair oxidative damage with Hyperbaric Oxygen therapy and the use of antioxidant nutritional supplements including Vitamins E, Vitamin B12 and folate, amino acids, and fatty acids as well as the intake of “superfoods” known for their natural healing properties.
In addition, we utilize intravenous vitamin infusions to help regulate any nutrient imbalances and vitamin and mineral deficiencies. To balance the flow of energy and help promote clearer thinking, we also utilize ONDAMED®, a high-tech biofeedback machine designed in Germany.
If you would like to explore options, please contact our office so we can start a conversation with you.
1 Ibrahim MM, Gabr MT. Multitarget therapeutic strategies for Alzheimer’s disease. Neural Regen Res. 2019 Mar;14(3):437-440. doi: 10.4103/1673-5374.245463.
2 Belaidi AA, Bush AI. Iron neurochemistry in Alzheimer’s disease and Parkinson’s disease: targets for therapeutics. J Neurochem. 2016 Oct;139 Suppl 1:179-197. doi: 10.1111/jnc.13425. Epub 2016 Feb 10.
3 Guo C, Liu JL, Fan YG, Yang ZS, Wang ZY. Iron and Alzheimer’s disease: From Pathogenesis to Therapeutic Implications. Frontiers in neuroscience. 2018;12:632.
4 Chung JY, Kim HS, Song J. Iron metabolism in diabetes-induced Alzheimer’s disease: a focus on insulin resistance in the brain. Biometals. 2018;31(5):705-714.